TY - JOUR TI - Case Report: 100-year-old COVID-positive Hip Fracture Patient for Hemiarthroplasty Under Spinal Anesthesia AU - Beathe, Jonathan C. AU - Memtsoudis, Stavros G. T2 - Gerontology and Geriatric Medicine AB - Elderly patients undergoing hip fracture surgery represent a myriad of perioperative challenges and risks. The arrival of the global pandemic of novel coronavirus disease 2019 (COVID-19) adds an unprecedented challenge to the management of hip fracture patients. We describe the unique experience and favorable outcome of a 100-year-old COVID-positive hip fracture patient that underwent spinal anesthesia for hemiarthroplasty and subsequent hydroxychloroquine (HCQ) therapy. Multiple factors of varying known benefit may have contributed to our outcome, including preoperative medical consultation and assessment, early surgical intervention, regional anesthesia with little to no sedation, early mobilization and HCQ therapy. DA - 2020/01// PY - 2020 DO - 10.1177/2333721420956766 DP - DOI.org (Crossref) VL - 6 SP - 233372142095676 J2 - Gerontology and Geriatric Medicine LA - en SN - 2333-7214, 2333-7214 ST - Case Report UR - http://journals.sagepub.com/doi/10.1177/2333721420956766 Y2 - 2020/11/30/08:05:27 L1 - https://journals.sagepub.com/doi/pdf/10.1177/2333721420956766 ER - TY - JOUR TI - Ischemic Stroke Occurs Less Frequently in Patients With COVID-19: A Multicenter Cross-Sectional Study AU - Bekelis, Kimon AU - Missios, Symeon AU - Ahmad, Javaad AU - Labropoulos, Nicos AU - Schirmer, Clemens M. AU - Calnan, Daniel R. AU - Skinner, Jonathan AU - MacKenzie, Todd A. T2 - Stroke AB - Background and Purpose: The impact of coronavirus disease 2019 (COVID-19) on the occurrence of ischemic stroke has been the subject of increased speculation but has not been confirmed in large observational studies. We investigated the association between COVID-19 and stroke. Methods: We performed a cross-sectional study involving patients discharged from a healthcare system in New York State, from January to April 2020. A mixed-effects logistic regression analysis and a propensity score–weighted analysis were used to control for confounders and investigate the association of COVID-19 with ischemic stroke. Similar techniques were used to detect the impact of concurrent COVID-19 infection on unfavorable outcomes for patients with stroke. Results: Among 24 808 discharges, 2513 (10.1%) were diagnosed with COVID-19, and 566 (0.2%) presented with acute ischemic stroke. Patients diagnosed with COVID-19 were at one-quarter the odds of stroke compared with other patients (odds ratio, 0.25 [95% CI, 0.16–0.40]). This association was consistent in all age groups. Our results were robust in sensitivity analyses, including propensity score–weighted regression models. In patients presenting with stroke, concurrent infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was associated with higher case-fatality (odds ratio, 10.50 [95% CI, 3.54–31.18]) and a trend towards increased occurrence of discharge to rehabilitation (odds ratio, 2.45 [95% CI, 0.81–1.25]). Conclusions: Using a comprehensive cross-section of patients from a large NY-based healthcare system, we did not identify a positive association between ischemic stroke and COVID-19. However, patients with stroke with COVID-19 had worse outcomes compared with those without, with over a 9-fold increase in mortality. Although no definitive conclusions can be reached from our observational study, our data do not support the concerns for an epidemic of stroke in young adults with COVID-19. DA - 2020/12// PY - 2020 DO - 10.1161/STROKEAHA.120.031217 DP - DOI.org (Crossref) VL - 51 IS - 12 SP - 3570 EP - 3576 J2 - Stroke LA - en SN - 0039-2499, 1524-4628 ST - Ischemic Stroke Occurs Less Frequently in Patients With COVID-19 UR - https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031217 Y2 - 2020/11/30/08:05:35 L1 - https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.120.031217 ER - TY - JOUR TI - Third Cranial Nerve Palsy Presenting with Unilateral Diplopia and Strabismus in a 24-Year-Old Woman with COVID-19 AU - Belghmaidi, Sarah AU - Nassih, Houda AU - Boutgayout, Saloua AU - El Fakiri, Karima AU - El Qadiry, Rabiy AU - Hajji, Ibtissam AU - Bourrahouat, Aicha AU - Moutaouakil, Abdeljalil T2 - American Journal of Case Reports DA - 2020/09/07/ PY - 2020 DO - 10.12659/AJCR.925897 DP - DOI.org (Crossref) VL - 21 J2 - Am J Case Rep LA - en SN - 1941-5923 UR - https://www.amjcaserep.com/abstract/index/idArt/925897 Y2 - 2020/11/30/08:05:49 L1 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571280/pdf/amjcaserep-21-e925897.pdf ER - TY - JOUR TI - Incidence of thrombotic outcomes for patients hospitalized and discharged after COVID-19 infection AU - Bourguignon, Alex AU - Beaulieu, Camille AU - Belkaid, Wiam AU - Desilets, Antoine AU - Blais, Normand T2 - Thrombosis Research DA - 2020/12// PY - 2020 DO - 10.1016/j.thromres.2020.10.017 DP - DOI.org (Crossref) VL - 196 SP - 491 EP - 493 J2 - Thrombosis Research LA - en SN - 00493848 UR - https://linkinghub.elsevier.com/retrieve/pii/S0049384820305612 Y2 - 2020/11/30/08:05:58 L1 - https://www.thrombosisresearch.com/article/S0049384820305612/pdf ER - TY - JOUR TI - Possible affective cognitive cerebellar syndrome in a young patient with COVID-19 CNS vasculopathy and stroke AU - Chia, Kai Xin AU - Polakhare, Sonali AU - Bruno, Stefania Dafne T2 - BMJ Case Reports AB - Early case series suggest that about one-third of patients with COVID-19 present with neurological manifestations, including cerebrovascular disease, reported in 2%–6% of hospitalised patients. These are generally older patients with severe infection and comorbidities. Here we discuss the case of a previously fit and well 39-year-old man who presented with fever and respiratory symptoms, evolving in pneumonia with hypoxia but only requiring continuous positive airway pressure. After resolution of the respiratory disease, the patient developed focal neurology and was found to have bilateral occipital, thalamic and cerebellar infarcts. A diagnosis of COVID-19 central nervous system vasculopathy was made. He developed a florid neuropsychiatric syndrome, including paranoia, irritability, aggression and disinhibition, requiring treatment with antipsychotics and transfer to neurorehabilitation. Neuropsychometry revealed a wide range of cognitive deficits. The rapid evolution of the illness was matched by fast resolution of the neuropsychiatric picture with mild residual cognitive impairment. DA - 2020/10// PY - 2020 DO - 10.1136/bcr-2020-237926 DP - DOI.org (Crossref) VL - 13 IS - 10 SP - e237926 J2 - BMJ Case Rep LA - en SN - 1757-790X UR - https://casereports.bmj.com/lookup/doi/10.1136/bcr-2020-237926 Y2 - 2020/11/30/08:06:16 L1 - https://casereports.bmj.com/content/bmjcr/13/10/e237926.full.pdf ER - TY - JOUR TI - Follow up of patients with severe coronavirus disease 2019 (COVID-19): Pulmonary and extrapulmonary disease sequelae AU - Daher, Ayham AU - Balfanz, Paul AU - Cornelissen, Christian AU - Müller, Annegret AU - Bergs, Ingmar AU - Marx, Nikolaus AU - Müller-Wieland, Dirk AU - Hartmann, Bojan AU - Dreher, Michael AU - Müller, Tobias T2 - Respiratory Medicine DA - 2020/11// PY - 2020 DO - 10.1016/j.rmed.2020.106197 DP - DOI.org (Crossref) VL - 174 SP - 106197 J2 - Respiratory Medicine LA - en SN - 09546111 ST - Follow up of patients with severe coronavirus disease 2019 (COVID-19) UR - https://linkinghub.elsevier.com/retrieve/pii/S0954611120303371 Y2 - 2020/11/30/08:06:26 L1 - https://www.resmedjournal.com/article/S0954611120303371/pdf ER - TY - JOUR TI - Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study AU - De Lorenzo, Rebecca AU - Conte, Caterina AU - Lanzani, Chiara AU - Benedetti, Francesco AU - Roveri, Luisa AU - Mazza, Mario G. AU - Brioni, Elena AU - Giacalone, Giacomo AU - Canti, Valentina AU - Sofia, Valentina AU - D’Amico, Marta AU - Di Napoli, Davide AU - Ambrosio, Alberto AU - Scarpellini, Paolo AU - Castagna, Antonella AU - Landoni, Giovanni AU - Zangrillo, Alberto AU - Bosi, Emanuele AU - Tresoldi, Moreno AU - Ciceri, Fabio AU - Rovere-Querini, Patrizia T2 - PLOS ONE A2 - Adrish, Muhammad DA - 2020/10/14/ PY - 2020 DO - 10.1371/journal.pone.0239570 DP - DOI.org (Crossref) VL - 15 IS - 10 SP - e0239570 J2 - PLoS ONE LA - en SN - 1932-6203 ST - Residual clinical damage after COVID-19 UR - https://dx.plos.org/10.1371/journal.pone.0239570 Y2 - 2020/11/30/08:06:39 L1 - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239570&type=printable ER - TY - JOUR TI - Myotonic dystrophy type 1 as a major risk factor for severe COVID-19? AU - Dhont, Sebastiaan AU - Callens, Rutger AU - Stevens, Dieter AU - Bauters, Fre AU - De Bleecker, Jan L. AU - Derom, Eric AU - Van Braeckel, Eva T2 - Acta Neurologica Belgica DA - 2020/10/14/ PY - 2020 DO - 10.1007/s13760-020-01514-z DP - DOI.org (Crossref) J2 - Acta Neurol Belg LA - en SN - 0300-9009, 2240-2993 UR - http://link.springer.com/10.1007/s13760-020-01514-z Y2 - 2020/11/30/08:06:47 L1 - https://link.springer.com/content/pdf/10.1007/s13760-020-01514-z.pdf ER - TY - JOUR TI - Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle Weakness AU - Ishkanian, Amy AU - Mehl, Alla T2 - Dysphagia DA - 2020/10/31/ PY - 2020 DO - 10.1007/s00455-020-10205-z DP - DOI.org (Crossref) J2 - Dysphagia LA - en SN - 0179-051X, 1432-0460 ST - Clinical Conundrum UR - http://link.springer.com/10.1007/s00455-020-10205-z Y2 - 2020/11/30/08:06:57 L1 - https://link.springer.com/content/pdf/10.1007/s00455-020-10205-z.pdf ER - TY - JOUR TI - Predictors of functional dependence after COVID-19: A retrospective examination among veterans AU - Leigh, Alexandra E. AU - McCall, Jonathan AU - Burke, Rebecca V. AU - Rome, Robin AU - Raines, Amanda M. T2 - American Journal of Physical Medicine & Rehabilitation DA - 2020/10/12/ PY - 2020 DO - 10.1097/PHM.0000000000001614 DP - DOI.org (Crossref) VL - Publish Ahead of Print LA - en SN - 0894-9115 ST - Predictors of functional dependence after COVID-19 UR - https://journals.lww.com/10.1097/PHM.0000000000001614 Y2 - 2020/11/30/08:07:10 ER - TY - JOUR TI - Peripheral facial nerve palsy associated with COVID-19 AU - Lima, Marco A. AU - Silva, Marcus Tulius T. AU - Soares, Cristiane N. AU - Coutinho, Renan AU - Oliveira, Henrique S. AU - Afonso, Livia AU - Espíndola, Otávio AU - Leite, Ana Claudia AU - Araujo, Abelardo T2 - Journal of NeuroVirology DA - 2020/10/02/ PY - 2020 DO - 10.1007/s13365-020-00912-6 DP - DOI.org (Crossref) J2 - J. Neurovirol. LA - en SN - 1355-0284, 1538-2443 UR - http://link.springer.com/10.1007/s13365-020-00912-6 Y2 - 2020/11/30/08:07:14 L1 - https://link.springer.com/content/pdf/10.1007/s13365-020-00912-6.pdf ER - TY - JOUR TI - Evolução funcional da deglutição em pacientes com COVID-19 internados em UTI AU - Lima, Maíra Santilli de AU - Sassi, Fernanda Chiarion AU - Medeiros, Gisele Chagas de AU - Ritto, Ana Paula AU - Andrade, Claudia Regina Furquim de T2 - CoDAS AB - RESUMO Objetivo descrever a evolução funcional da deglutição em pacientes com COVID-19 submetidos à intervenção fonoaudiológica na Unidade de Tratamento Intensivo (UTI). Método participaram do estudo 77 pacientes (ambos os gêneros; idade média 53.4±15.9; escore na Escala de Coma de Glasgow ≥14; e condição respiratória estável). A escala funcional utilizada para a avaliação da deglutição foi a American Speech-Language-Hearing Association National Outcome Measurement System (ASHA NOMS). Resultados os resultados indicam que houve recuperação significativa nos padrões funcionais da deglutição na comparação pré e pós-intervenção fonoaudiológica. Conclusão 83% dos pacientes necessitam de até 3 intervenções para a recuperação dos padrões seguros de deglutição. , ABSTRACT Purpose to describe de functional development of swallowing in Intensive Care Unit (ICU) patients with COVID-19, who were submitted to a swallowing intervention. Methods participants of the study were 77 patients (both gender, mean age 53.4±15.9; score on the Glasgow Coma Scale ≥14 and stable respiratory condition). The functional scale of swallowing used for assessment was the American Speech-Language-Hearing Association National Outcome Measurement System (ASHA NOMS). Results the results indicate that there was a significant recovery of the functional swallowing patterns when comparing the measurements pre and post swallowing intervention. Conclusion 83% of the patients needed up to 3 swallowing interventions to recover a safe swallowing pattern. DA - 2020/// PY - 2020 DO - 10.1590/2317-1782/20192020222 DP - DOI.org (Crossref) VL - 32 IS - 4 SP - e20200222 J2 - CoDAS SN - 2317-1782 UR - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822020000400501&tlng=pt Y2 - 2020/11/30/08:07:19 L1 - https://www.scielo.br/pdf/codas/v32n4/en_2317-1782-codas-32-4-e20200222.pdf ER - TY - JOUR TI - Functional and cognitive outcomes after COVID-19 delirium AU - Mcloughlin, Benjamin C. AU - Miles, Amy AU - Webb, Thomas E. AU - Knopp, Paul AU - Eyres, Clodagh AU - Fabbri, Ambra AU - Humphries, Fiona AU - Davis, Daniel T2 - European Geriatric Medicine AB - Abstract Purpose To ascertain delirium prevalence and outcomes in COVID-19. Methods We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. Results In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p  = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. Conclusions Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. DA - 2020/10// PY - 2020 DO - 10.1007/s41999-020-00353-8 DP - DOI.org (Crossref) VL - 11 IS - 5 SP - 857 EP - 862 J2 - Eur Geriatr Med LA - en SN - 1878-7657 UR - http://link.springer.com/10.1007/s41999-020-00353-8 Y2 - 2020/11/30/08:07:38 L1 - https://link.springer.com/content/pdf/10.1007/s41999-020-00353-8.pdf ER - TY - JOUR TI - Heterotopic ossification in COVID-19: A series of 4 cases AU - Meyer, C. AU - Haustrate, M.-A. AU - Nisolle, J.F. AU - Deltombe, T. T2 - Annals of Physical and Rehabilitation Medicine DA - 2020/11// PY - 2020 DO - 10.1016/j.rehab.2020.09.010 DP - DOI.org (Crossref) VL - 63 IS - 6 SP - 565 EP - 567 J2 - Annals of Physical and Rehabilitation Medicine LA - en SN - 18770657 ST - Heterotopic ossification in COVID-19 UR - https://linkinghub.elsevier.com/retrieve/pii/S1877065720301913 Y2 - 2020/11/30/08:07:48 L1 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587134/pdf/main.pdf ER - TY - JOUR TI - COVID-19 impact on consecutive neurological patients admitted to the emergency department AU - Pilotto, Andrea AU - Benussi, Alberto AU - Libri, Ilenia AU - Masciocchi, Stefano AU - Poli, Loris AU - Premi, Enrico AU - Alberici, Antonella AU - Baldelli, Enrico AU - Bonacina, Sonia AU - Brambilla, Laura AU - Benini, Matteo AU - Caratozzolo, Salvatore AU - Cortinovis, Matteo AU - Costa, Angelo AU - Cotti Piccinelli, Stefano AU - Cottini, Elisabetta AU - Cristillo, Viviana AU - Delrio, Ilenia AU - Filosto, Massimiliano AU - Gamba, Massimo AU - Gazzina, Stefano AU - Gilberti, Nicola AU - Gipponi, Stefano AU - Giunta, Marcello AU - Imarisio, Alberto AU - Liberini, Paolo AU - Locatelli, Martina AU - Schiano, Francesca AU - Rao, Ranata AU - Risi, Barbara AU - Rozzini, Luca AU - Scalvini, Andrea AU - Vergani, Veronica AU - Volonghi, Irene AU - Zoppi, Nicola AU - Borroni, Barbara AU - Magoni, Mauro AU - Leonardi, Matilde AU - Zanusso, Gianluigi AU - Ferrari, Sergio AU - Mariotto, Sara AU - Pezzini, Alessandro AU - Gasparotti, Roberto AU - Paolillo, Ciro AU - Padovani, Alessandro T2 - Journal of Neurology, Neurosurgery & Psychiatry DA - 2020/10/14/ PY - 2020 DO - 10.1136/jnnp-2020-323929 DP - DOI.org (Crossref) SP - jnnp EP - 2020-323929 J2 - J Neurol Neurosurg Psychiatry LA - en SN - 0022-3050, 1468-330X UR - https://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2020-323929 Y2 - 2020/11/30/08:08:13 L1 - https://jnnp.bmj.com/content/jnnp/early/2020/10/14/jnnp-2020-323929.full.pdf ER - TY - JOUR TI - Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up” AU - Pirau, Letitia AU - Ottenhoff, Lauren AU - Williamson, Craig A. AU - Ahmad, Shahid N. AU - Wabl, Rafael AU - Nguyen, Andrew AU - Faiver, Laura AU - Rajajee, Venkatakrishna T2 - Frontiers in Neurology DA - 2020/09/23/ PY - 2020 DO - 10.3389/fneur.2020.00964 DP - DOI.org (Crossref) VL - 11 SP - 964 J2 - Front. Neurol. SN - 1664-2295 ST - Case Series UR - https://www.frontiersin.org/article/10.3389/fneur.2020.00964/full Y2 - 2020/11/30/08:08:26 L1 - https://www.frontiersin.org/articles/10.3389/fneur.2020.00964/pdf ER - TY - JOUR TI - A Case of Guillain-Barré Syndrome Associated With COVID-19 AU - Rajdev, Kartikeya AU - Victor, Navin AU - Buckholtz, Elaine S. AU - Hariharan, Praveen AU - Saeed, Muhammad Ahsan AU - Hershberger, Daniel M. AU - Bista, Sabin T2 - Journal of Investigative Medicine High Impact Case Reports AB - A novel member of human RNA coronavirus, which is an enveloped betacoronavirus, has been termed severe acute respiratory syndrome coronavirus-2 (SARS COV-2). The illness caused by SARS COV-2 is referred to as the coronavirus disease 2019 (COVID-19). It is a highly contagious disease that has resulted in a global pandemic. The clinical spectrum of COVID-19 ranges from asymptomatic illness to acute respiratory distress syndrome, septic shock, multi-organ dysfunction, and death. The most common symptoms include fever, fatigue, dry cough, dyspnea, and diarrhea. Neurological manifestations have also been reported. However, the data on the association of Guillain-Barré syndrome (GBS) with COVID-19 are scarce. We report a rare case of a COVID-19-positive 36-year-old immunocompromised male who presented with clinical features of GBS. His clinical examination showed generalized weakness and hyporeflexia. The cerebrospinal fluid (CSF) analysis showed albuminocytological dissociation. Intravenous immunoglobulin (IVIG) was administered based on the high clinical suspicion of GBS. The patient’s neurological condition worsened with progression to bulbar weakness and ultimately neuromuscular respiratory failure requiring mechanical ventilation. His nerve conduction studies were consistent with demyelinating polyneuropathy. He received five plasma exchange treatments and was successfully weaned from mechanical ventilation. A brain and cervical spine magnetic resonance imaging was obtained to rule out other causes, which was normal. COVID-19 is believed to cause a dysregulated immune system, which likely plays an important role in the neuropathogenesis of GBS. DA - 2020/01// PY - 2020 DO - 10.1177/2324709620961198 DP - DOI.org (Crossref) VL - 8 SP - 232470962096119 J2 - Journal of Investigative Medicine High Impact Case Reports LA - en SN - 2324-7096, 2324-7096 UR - http://journals.sagepub.com/doi/10.1177/2324709620961198 Y2 - 2020/11/30/08:08:42 L1 - https://journals.sagepub.com/doi/pdf/10.1177/2324709620961198 ER - TY - JOUR TI - COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center AU - Requena, Manuel AU - Olivé-Gadea, Marta AU - Muchada, Marian AU - García-Tornel, Álvaro AU - Deck, Matías AU - Juega, Jesús AU - Boned, Sandra AU - Rodríguez-Villatoro, Noelia AU - Piñana, Carlos AU - Pagola, Jorge AU - Rodríguez-Luna, David AU - Hernández, David AU - Rubiera, Marta AU - Tomasello, Alejandro AU - Molina, Carlos A. AU - Ribo, Marc T2 - Journal of Stroke and Cerebrovascular Diseases DA - 2020/11// PY - 2020 DO - 10.1016/j.jstrokecerebrovasdis.2020.105225 DP - DOI.org (Crossref) VL - 29 IS - 11 SP - 105225 J2 - Journal of Stroke and Cerebrovascular Diseases LA - en SN - 10523057 ST - COVID-19 and Stroke UR - https://linkinghub.elsevier.com/retrieve/pii/S1052305720306431 Y2 - 2020/11/30/08:08:48 L1 - https://www.strokejournal.org/article/S1052305720306431/pdf ER - TY - JOUR TI - Ambulatory Rehabilitation of Patients Hospitalized with SARS CoV‐2 Infections: Early Pandemic Experience in New York City and Boston AU - Steere, Hannah K. AU - Polich, Ginger AU - Silver, Julie K. AU - Hameed, Farah AU - Gellhorn, Alfred C. AU - Borg‐Stein, Joanne AU - Schneider, Jeffrey C. T2 - PM&R DA - 2020/10/07/ PY - 2020 DO - 10.1002/pmrj.12506 DP - DOI.org (Crossref) SP - pmrj.12506 J2 - PM&R LA - en SN - 1934-1482, 1934-1563 ST - Ambulatory Rehabilitation of Patients Hospitalized with